Publications

Lipid mediators generated by the cytochrome P450—Epoxide hydrolase pathway.

Frömel T, Hu J, Fleming I. Adv Pharmacol 2023;97:327–373. doi: 10.1016/bs.apha.2022.12.004.

11,12-EET regulates PPAR-γ expression to modulate TGF-β-mediated macrophage polarization.

Li X, Kempf S, Günther S, Hu J, Fleming I. Cells 2023;12:700. doi: 10.3390/cells12050700.

Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts.

Edin M, Gruzdev A, Bradbury JA, Graves J, Lih F, DeGraff L, Fleming I, Zeldin D. J Biol Chem. 2023;103049. doi: 10.1016/j.jbc.2023.103049.

Endothelial dependent S-sulfhydration of tissue factor pathway inhibitor regulates blood coagulation.

Wittig J, Drekolia M-K, Kyselova A, Delgado Lagos F, Bochenek ML, Hu J, Schäfer K, Fleming I, Bibli S-I. Redox Biol. 2023;62:102694. doi:10.1016/j.redox.2023.102694.

Cardiovascular functions of Ena/VASP proteins: past, present and beyond.

Benz PM, Frömel T, Laban H, Zink J, Ulrich L, Groneberg D, Boon RA, Poley P, Renne T, De Wit C, Fleming I. Cells. 2023;12:1740. doi: 10.3390/cells12131740.

Disrupted binding of cystathionine γ-lyase to p53 promotes endothelial senescence.

Hu J, Leisegang MS, Looso M,  Drekolia M-K, Wittig J , Mettner J,  Karantanou C, Kyselova A , Dumbovic G, Li X, Li Y, Guenther S, John D,  Siragusa M, Zukunft S , Oo J, Wittig I, Hille S, Weigert A, Knapp S, Brandes RP, Müller OJ, Papapetropoulos A, Sigala F, Dobreva G, Kojonazarov B, Fleming I* , Bibli S-I*.  Circ Res. 2023;133:842–857. doi: 10.1161/circresaha.123.323084. (Editorial: Transcriptional control of endothelial senescence and vascular repair. El-Osta A.  Circ Res. 2023;133:858–860. doi: 10.1161/CIRCRESAHA.123.323716.)

Vasostatin-2, angiogenesis and collateral function.

Fleming I. Eur Heart J. 2023:44(19); 1745-1747 doi: 10.1093/eurheartj/ehad052

Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: a clinical consensus statement from the ESC Working Group on Coronary Pathophysiology and Microcirculation.

Antoniades C, Tousoulis D, Vavlukis M, Fleming I, Duncker DJGM, Eringa E, Manfrini O, Antonopoulos AS, Oikonomou E, Padró T, Trifunovic D, De Luca G, Guzik T, Cenko E, Djordjevic-Dikic A, Crea F. Eur Heart J. 2023;44:3827–3844. doi: 10.1093/eurheartj/ehad484.

Long non-coding RNA ADPGK-AS1 regulates macrophage mitochondrial and phenotypic state – impact on lung cancer.

Karger A, Mansouri S, Leisegand MS, Weigert A, Günther S, Kuenne C, Wittig I, Zukunft S, Klatt S, Fleming I, Ruppert C, Witte B, Alkoudmani I, Gattenlöhner S, Grimminger F, Seeger W, Pullamsetti SS, Savai R. EMBO J. 2023;e111620. doi: 10.15252/embj.2022111620.

A transient increase of HIF-1α during the G1 phase (G1-HIF) ensures cell survival under nutritional stress.

Belapurkar R, Werner S, Fleming I, Kracht M, Zukunft S, Pfisterer M, Dreute J, Schmitz ML. Cell Death Dis 2023;14:477. doi: 10.1038/s41419-023-06012-7.

Inhibition of fatty acid oxidation stimulates KDM5-mediated H3K4me3 demethylation and enables heart regeneration in adult mice.

Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Klatt S, Zukunft S, Fleming I, Poschet G, Wietrlmann A, Atzberger A, Potente M, Yuan X, Braun T. Nature. 2023. doi: 10.1038/s41586-023-06585-5.

Epoxyeicosatrienoic acids and sEH inhibition prevent cardiac dysfunction in CVB3-induced myocarditis by positively regulating type I interferon signaling.

Zhou Z, Zhang M, Zhao C, Gao X, Wen Z, Wu J, Chen C, Hu J, Fleming I, Wang DW. Circ Res. 2023;133:772–788. doi: 10.1161/CIRCRESAHA.123.322619.

*Indicates that the authors contributed equally; bold names = IVS members

Cytochrome P450-derived lipid mediators in angiogenesis and stem cell biology.

Frömel T, Naeem Z, Pirzeh L, Fleming I. Pharmacol Ther. 2022;234:108049. doi: 10.1016/j.pharmthera.2021.108049.

Development and characterization of a fluorescent ligand for leukotriene B4 receptor 2 in cells and tissues.

Heering J, Hernandez-Olmos V, Ildefeld N, Liu T, Kaiser A, Naeem Z, Frömel T, Fleming I, Steinhilber D, Proschak E. J Med Chem. 2022;65:2023-2034. doi: 10.1021/acs.jmedchem.1c01589.

Disrupting prostaglandin E2 signaling in cancer-associated fibroblasts limits mammary carcinoma growth but promotes metastasis.

Elwakeel E, Brüggemann M, Wagih J, Litagina O, Elewa MAF, Han Y, Frömel T, Popp R, Nicolas AM, Schreiber Y, Gradhand E, Thomas D, Nüsing R, Steinmetz-Späh J, Savai R, Fokas E, Fleming I, Greten F, Zarnack K, Brüne B, Weigert A. Cancer Res. 2022;82:1380–1395. doi: 10.1158/0008-5472.CAN-21-2116.

Phosphodiesterase S-sulfhydration contributes to the anomalous skeletal muscle function.

Vellecco V, Panza E, Bibli S-I, Casillo GM, Raucci F, Smimmo M, Villani R, Cavezza MR, Fleming I, di Villa Bianca Rd, Maione F, Cirino G, Bucci M. Pharmacol Res. 2022;177;106108. doi: 10.1016/j.phrs.2022.106108.

Phosphatidylserine synthase PTDSS1 shapes the tumor lipidome to maintain tumor-promoting inflammation.

Sekar D, Dillmann C, Sirait-Fischer E, Fink AF, Zivkovic A, Baum N, Strack E, Klatt S, Zukunft S, Wallner S, Descot A, Olesch C, da Silva P, Knethen A von, Schmid T, Grösch S, Savai R, Ferreirós N, Fleming I, Ghosh S, Rothlin CV, Stark H, Medyouf H, Brüne B, Weigert A. Cancer Res. 2022;82:1617–1632. doi: 10.1158/0008-5472.CAN-20-3870.

Loss of endothelial cytochrome P450 reductase induces vascular dysfunction in mice.

Malacarne PF, Ratiu C, Gajos-Draus A, Müller N, Lopez M, Pflüger-Müller B, Ding X, Warwick T, Oo J, Siragusa M, Angioni C, Günther S, Weigert A, Geißlinger G, Lütjohann D, Schunck W-H, Fleming I, Brandes RP. Hypertension. 2022;79:1216–1226. doi: 10.1161/HYPERTENSIONAHA.121.18752.

MPST maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity.

Katsouda A, Valakos D, Dionellis VS, Bibli S-I, Akoumianakis I, Karaliota S, Zuhra K, Fleming I, Nagahara N, Havaki S, Gorgoulis VG, Thanos D, Antoniades C, Szabo C, Papapetropoulos A. J Exp Med. 2022; 219:e20211894. doi: 10.1084/jem.20211894.

Effect of thrombin on the metabolism and function of murine macrophages.

Ukan Ü, Delgado Lagos F, Kempf S, Günther S, Siragusa M, Fisslthaler B, Fleming I. Cells. 2022;11:1718. doi: 10.3390/cells11101718.

Association of clonal hematopoiesis of indeterminate potential with inflammatory gene expression in patients with COPD.

Kuhnert S, Mansouri S, Rieger M, Savai R, Avci E, Díaz-Pina G, Padmaseker M, Looso M, Hadzic S, Acker T, Klatt S, Wilhem J, Fleming I, Sommer N, Weissmann N, Vogelmeier C, Bals R, Zeiher AM, Dimmeler S, Pullamsetti S. Cells. 2022;11:2121. doi: 10.3390/cells11132121.

Role of the soluble epoxide hydrolase in the hair follicle stem cell homeostasis and hair growth.

Naeem Z, Zukunft S, Günther S, Liebner S, Weigert A, Hammock BD, Frömel T, Fleming I. Pflüger’s Arch Eur J Pharmacol. 2022;474:1021-1035. doi: 10.1007/s00424-022-02709-4.

Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation.

Tousoulis D, Guzik T, Padro T, Duncker DJ, Luca G de, Eringa E, Vavlukis M, Antonopoulos AS, Katsimichas T, Cenko E, Djordjevic-Dikic A, Fleming I, Manfrini O, Trifunovic D, Antoniades C, Crea F. Cardiovasc Res. 2022;118:3171–3182. doi: 10.1093/cvr/cvac057.

Sustained Endurance Training Leads to Metabolomic Adaptation.

Weiss A, Katharina Alack K., Klatt S, Zukunft S, Schermuly R, Frech T., Mooren F.-C., Krüger K. Metabolites. 2022 Jul; 12(7): 658. doi: 10.3390/metabo12070658

Unravelling the impact of aging on the human endothelial lncRNA transcriptome.

Drekolia MK , Talyan S, Cordellini Emídio R, Boon RA, Guenther S, Looso M, Dumbović G, Bibli SI . FRONT GENET. 2022;13:1035380. doi: 10.3389/fgene.2022.1035380. eCollection 2022.

*Indicates that the authors contributed equally; bold names = IVS members

Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction.

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg E-M, Manavsji Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli S-I, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S. Nat Commun. 2021;12:681. doi: 10.1038/s41467-021-20905-1.

EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis.

Zink J, Frömel T, Weigert A, Stingl H, Frye M, Laban H, Günther L, Hu J, John D, Salinas G, Popp R, Renné T, Vanhollebeke B, Acker-Palmer A, Fleming I, Benz PM. EMBO Rep. 2021;22:e48961. doi: 10.15252/embr.201948961.

Apoptotic cells induce proliferation of peritoneal macrophages.

Knuth A-K, Huard A, Naeem Z, Rappl P, Bauer R, Mota AC, Schmidt T, Fleming I, Fulda S, Weigert A. Int J Mol Sci. 2021; 22:2230. doi: 10.3390/ijms22052230.

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets.

Wang B, Wu L, Chen J, Dong L, Chen C, Wen Z, Hu J, Fleming I, Wang DW. Signal Transduct Target Ther. 2021;6:94. doi: 10.1038/s41392-020-00443-w.

Human platelets are a source of collagen I.

Kyselova A, Zukunft S, Puppe D, Wittig I, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V. Hematologica. 2021;106(3):899-902. doi: 10.3324/haematol.2020.255612.

Mapping the endothelial cell S-sulfhydrome highlights the crucial role of integrin sulfhydration in vascular function.

Bibli S-I, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. Circulation. 2021;143:935–948. doi: 10.1161/CIRCULATIONAHA.120.051877.

Secreted modular calcium binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes.

Delgado Lagos F, Elgheznawy A, Kyselova A, Meyer zu Heringdorf D, Ratiu C, Randriamboavonjy V, Mann AW, Fisslthaler B, Siragusa M, Fleming I. Blood. 2021;137:1641–1651. doi: 10.1182/blood.2020009405.

Combined cardioprotective and adipocyte browning effects promoted by the eutomer of dual sEH/PPARγ modulator.

Hartmann M, Bibli S-I, Tews D, Ni X, Kircher T, Kramer J, Kilu W, Heering J, Hernandez Olmos V, Weizel L, Scriba G, Krait S, Knapp S, Chaikuad A, Merk D, Fleming I, Fischer-Posovszky P, Proschak E. J Med Chem. 2021;64(5):2815-2828. doi: 10.1021/acs.jmedchem.0c02063.

AGMO inhibitor reduces 3T3-L1 adipogenesis.

Fischer C, Willken-Schmitz A, Hernandez-Olmos V, Proschak E, Stark H, Fleming I, Weigert A, Thurn M, Hofmann M, Werner ER, Geisslinger G, Niederberger E, Watschinger K, Tegeder I. Cells. 2021;10:1081. doi: 10.3390/cells10051081.

VE-PTP inhibition elicits eNOS phosphorylation and activity to blunt endothelial dysfunction and hypertension in diabetes.

Siragusa M, Justo AFO, Malacarne PF, Strano A, Buch A, Withers B, Peters KG, Fleming I. Cardiovasc Res. 2021;117:1546–1556. doi: 10.1093/cvr/cvaa213. (Editorial Arishe OO, Webb RC. VE-PTP Inhibition: a novel therapeutic target for hypertension in diabetic patients. Cardiovasc Res. 2021;117:1423-1425).

Who’s afraid of being a reviewer? An A-Z of tips and tricks for peer review.

Fleming I. CVR Onlife. 2021;117(8):e104-e105. doi: 10.1093/cvr/cvab180.

The consequences of soluble epoxide hydrolase deletion on tumorigenesis and metastasis in a mouse model of breast cancer.

Kesevan R, Frömel T, Zukunft S, Brüne B, Weigert A, Wittig I, Popp R, Fleming I. Int J Mol Med 2021; 22:7120. doi: 10.3390/ijms22137120.

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.

Wagner JUG, Bojkova D, Shumliakivska M, Luxán G, Nicin L, Aslan GS, Milting H, Kandler JD, Dendorfer A, Heumueller AW, Fleming I, Bibli S-I, Jakobi T, Dieterich C, Zeiher AM, Ciesek S, Cinatl J, Dimmeler S. Basic Res Cardiol. 2021;116:42. doi: 10.1007/s00395-021-00882-8.

Cyp2c44 epoxygenase-derived epoxyeicosatrienoic acids in vascular smooth muscle cells elicits vasoconstriction of the murine ophthalmic artery.

Hu J, Brecht R, Sisignano M, Angioni C, Bibli I-S, Perumal N, Fisslthaler B, Kleinert H, Gericke A, Pfeiffer N, Fleming I, Marnicam C. Sci Rep. 2021;11:18764. doi: 10.1038/s41598-021-98236-w.

miRNA-124 alleviates retinal vasoregression via regulating microglial polarization.

Chen Y, Lin J, Schlotterer A, Kurowski L, Hoffmann S, Hammad S, Dooley S, Buchholz M, Hu J, Fleming I, Hammes HP. Int J Mol Sci. 2021;22:11068. doi: 10.3390/ijms222011068.

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.

Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, Günther S, Siebenbrodt K, Kestner R-I, Kuhlmann T, Fleming I, Offermanns S, Wettschureck N. Nat Commun. 2021;12:6798. doi: 10.1038/s41467-021-26882-9.

Oxidative post translational modifications: a focus on cysteine S-sulfhydration and the regulation of endothelial fitness.

Bibli I-S, Fleming I. Antioxid Redox Signal 2021;35:1494-1514 doi: 10.1089/ars.2021.0162.

A prickly situation: competitive antagonism by different hedgehog proteins.

Fleming I. Cardiovasc Res. 2021:117(12):2411-2413. doi:10.1093/cvr/cvab037

Validation of candidate phospholipid biomarkers of chronic kidney disease in hyperglycemic individuals and their organ-specific exploration in leptin receptor-deficient db/db mouse.

Huang J, Covic M, Huth C, Rommel M, Adam J, Zukunft S , Prehn C, Wang L, Nano J, Scheerer MF, Neschen S, Kastenmüller G, Gieger C, Laxy M, Schliess F, Adamski J, Suhre K, de Angelis MH, Peters A, Wang-Sattler R. Metabolites 2021;11(2). 89 doi: 10.3390/metabo11020089.

Vitamin D-A New Perspective in Treatment of Cerebral Vasospasm.

Kashefiolasl S, Leisegang MS, Helfinger V, Schürmann C, Pflüger-Müller B, Randriamboavonjy V, Vasconez AE, Carmeliet G, Badenhoop K, Hintereder G, Seifert V, Schröder K, Konczalla J, Brandes RP. Neurosurgery 2021 Feb 16;88(3):674-685. doi: 10.1093/neuros/nyaa484.

A six-metabolite panel as potential blood-based biomarkers for Parkinson’s disease.

Klatt S, Doecke JD, Roberts A, Boughton BA, Masters CL, Horne M, Roberts BR. NPJ Parkinsons Dis. 2021;7:94. doi: 10.1038/s41531-021-00239-x

Quantification of N-terminal amyloid-β isoforms reveals isomers are the most abundant form of the amyloid-β peptide in sporadic Alzheimer’s disease.

Mukherjee S, Perez KA, Lago LC, Klatt S, McLean CA, Birchall IE, Barnham KJ, Masters CL, Roberts BR. Brain Commun. 2021;3:fcab028. doi: 10.1093/braincomms/fcab028

Regulation of long non-coding RNAs by statins in atherosclerosis.

Tsilimigras DI, Bibli S-I, Siasos G, Oikonomou E, Perrea DN, Filis K, Tousoulis D, Sigala F. Biomolecules. 2021;11:623. doi: 10.3390/biom11050623.

NFAT5/TonEBP limits pulmonary vascular resistance in the hypoxic lung by controlling mitochondrial reactive oxygen species generation in arterial smooth muscle cells.

Laban, H., Siegmund, S., Zappe, M., Trogisch, F.A., Heineke, J., La Torre, C.D., Fisslthaler, B., Arnold, C., Lauryn, J., and Büttner, M., et al. (2021). Cells 10. doi.org/10.3390/cells10123293.

*Indicates that the authors contributed equally; bold names = IVS members

Shear stress regulates cystathionine gamma lyase expression to preserve endothelial redox balance and reduce membrane lipid peroxidation.

Bibli S-I, Hu J, Leisegang M, Wittig J, Kapasakalidi A, Zukunft S, FissIthaler B, Tsilimigras D, Brandes RP, Papapetropoulos A, Sigala F,* Fleming I.* Redox Biol. 2020;28:101379. doi: 10.1016/j.redox.2019.101379.

AKAP12 deficiency impairs VEGF-induced endothelial cell migration and sprouting.

Benz PM, Ding Y, Stingl H, Loot AE, Zink J, Wittig I, Popp R, Fleming I. Acta Physiol. 2020;228:e13325. doi: 10.1111/apha.13325. (Editorial: The role of AKAP12 in coordination of VEGF-induced endothelial cell motility. Walker-Gray R, Klussmann E. Acta Physiol (Oxf). 2020;228:e13359).

Anomalous Kv7 potassium channel activity in human malignant hyperthermia syndrome unmasks a key role for H2S and persulfidation in skeletal muscle.

Vellecco V, Martelli A, Bibli S-I, Vallifuoco M, Manzo OL, Panza E, Citi V, Calderone V, de Dominicis G, Cozzolino C, Mariniello M, Fleming I, Mancini A, Bucci M, Cirino G. Br J Pharmacol. 2020;177:810-823. doi: 10.1111/bph.14700.

Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis and metastasis in a mouse model of breast cancer.

Kesevan R, Frömel T, Zukunft S, Laban H, Geyer A, Naeem Z, Heidler J, Wittig I, Elwakeel E, Brüne B, Weigert A, Popp R, Fleming I. Proc Natl Acad Sci USA. 2020;117:5923-5930. doi: 10.1073/pnas.1921381117.

Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metaboic syndrome.

Dos Santos LRB, Fleming I. Prostaglandins Other Lipid Mediat. 2020;148:106407. doi: 10.1016/j.prostaglandins.2019.106407.

Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.

Peleli M, Bibli S-I, Li Z, Chatzianastasiou A, Varela A, Katsouda A, Zukunft S, Bucci MR, Vellecco V, Davos CH, Nagahara N, Cirino G, Fleming I, Lefer DJ, Papapetropoulos A. Biochem Pharmacol. 2020;176:113833. doi: 10.1016/j.bcp.2020.113833.

Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.

Wang SP, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschurek N, Honoré E, Offermanns S. Nat Commun. 2020;11:2303. doi: 10.1038/s41467-020-16026-w.

Protective effect of soluble epoxide hydrolase inhibition in retinal vasculopathy associated with polycystic kidney disease.

Lin J*, Hu J*, Schlotterer A, Wang J, Kolibabka M, Awwad K, Dietrich N, Breitschopf K, Wohlfart P, Kannt A, Lorenz K, Feng Y, Popp R, Hoffmann S, Fleming I, Hammes HP. Theranostics. 2020;10:7857-7871. doi: 10.7150/thno.43154.

Cyclin Y is expressed in platelets and modulates integrin outside-in signalling.

Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V. Int J Mol Mol Sci. 2020; 21:8239. doi: 10.3390/ijms21218239.

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats.

Mamazhakypov A, Weiß A, Zukunft S, Sydykov A, Kojonazarov B, Wilhelm J, Vroom C, Petrovic A, Kosanovic D, Weissmann N, Seeger W, Fleming I, Iglarz M, Grimminger F, Ghofrani HA, Schermuly RT. Pulm Circ. 2020;10:2045894020947283. doi: 10.1177/2045894020947283.

Platelet-derived calpain cleaves the endothelial protease-activated receptor 1 to induce vascular inflammation in diabetes.

Kyselova A, Elgheznawy A, Wittig I, Heidler J, Mann AW, Ruf W, Fleming I, Randriamboavonjy V. Basic Res Cardiol. 2020;115:75. doi: 10.1007/s00395-020-00833-9.

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics.

Govar AA, Törõ G, Szaniszlo P, Pavlidou A, Bibli SI, Thanki K, Resto VA, Chao C, Hellmich MR, Szabo C, Papapetropoulos A, Módis K. Br J Pharmacol. 2020;177:866-883. {Abdollahi, 2019 20040 /id}

Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase.

Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Proc Natl Acad Sci USA. 2020; 117(17):9497-9507. {Garcia, 2020 20051 /id}

Machine learning approaches reveal metabolic signatures of incident chronic kidney disease in individuals with prediabetes and type 2 diabetes.

Huang, Huth, Covic, Troll, Adam, Zukunft, Prehn, Wang, Nano, Scheerer, Neschen, Kastenmüller, Suhre, Laxy, Schliess, Gieger, Adamski, Hrabe de Angelis, Peters, Wang-Sattler. Diabetes 2020 69(12):2756-2765.

*Indicates that the authors contributed equally; bold names = IVS members

Cystathionine γ lyase sulfhydrates the RNA binding protein HuR to preserve endothelial cell function and delay atherosclerosis development.

Bibli S-I*, Hu J*, Sigala F, Wittig I, Heidler J, Zukunft S, Randriamboavonjy V, Wittig J, Siuda D, Kojonazarov B, Tsilimigras D, Schürmann C, Siragusa M, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I. Circulation. 2019;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757. (Editorial: HuR-ry Up. How Hydrogen Sulfide Protects Against Atherosclerosis. Barton & Meyer. Circulation 2019;139:115-118, and Highligned in “News” in Nat.Med. 14th Jan 2019 “Smelly Gas Protects Against Clogged Arteries”.)

Increased levels of arginase-containing platelet-derived microparticles leads to altered plasma arginine metabolism in polycystic ovary syndrome.

Kyselova A, Hinrichsmeyer H, Zukunft S, Mann AW, Dornauf I, Fleming I, Randriamboavonjy V. Metab -Clin Exp. 2019;90:16-9. doi: 10.1016/j.metabol.2018.10.008.

The histone demethylase Jarid1B mediates angiotensin II-induced endothelial dysfunction by controlling the 3’UTR of soluble epoxide hydrolase.

Vasconez AE, Janetzko P, Oo JA, Pflüger-Müller B, Ratiu C, Gu L, Helin K, Geisslinger G, Fleming I, Schröder K, Fork C, Brandes RP, Leisegang M. Acta Physiol. 2019;225:e13168. doi: 10.1111/apha.13168.

Redox-regulation of calpain and its consequence for vascular function.

Randriamboavonjy V, Kyselova A, Fleming I. Antiox Redox Signal. 2019;30(7):1011-1026. doi: 10.1089/ars.2018.7607.

ADAR1 is required for dendritic cell subset homeostasis and alveolar macrophage function.

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H. J Immunol. 2019;202(4):1099-1111. doi: 10.4049/jimmunol.1800269.

Chronic hypoxia enhances β-oxidation-dependent electron transport via electron transferring flavoproteins.

Fuhrman DC, Olesch C, Kurrle N, Schnuetgen F, Zukunft S, Fleming I, Brüne B. Cells. 2019;8:E172. doi: 10.3390/cells8020172.

Nitroglycerin limits infarct size through S-nitrosation of cyclophilin D: A novel mechanism for an old drug.

Bibli S-I, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steven S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I. Cardiovasc Res. 2019;115:625-636. doi: 10.1093/cvr/cvy222.

Epigenetic control of the angiotensin-converting enzyme in endothelial cells during inflammation.

Mudersbach T, Siuda D, Kohlstedt K, Fleming I. PLoS ONE. 2019;14:e0216218. doi: 10.1371/journal.pone.0216218.

Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.

Iring A, Jin Y-J, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. J Clin Invest. 2019;130//129:2775–2791. doi: 10.1172/JCI123825.

Myeloid-Specific Deletion of the AMPKα2 Subunit Alters Monocyte Protein Expression and Atherogenesis.

Fisslthaler B, Zippel N, Abdel Malik R, Delgado Lagos F, Zukunft S, Thöle J, Siuda D, Söhnlein O, Scholich K, Wittig I, Heidler J, Weigert A, Fleming I. Myeloid-specific deletion of the Int J Mol Sci. 2019;20:E3005. doi: 10.3390/ijms20123005.

New lipid mediators in retinal angiogenesis and retinopathy.

Fleming I. Front Pharmacol. 2019; 10:739. doi: 10.3389/fphar.2019.00739.

Pleiotropic effects of laminar flow and statins depend on the Krüppel-like factor-induced lncRNA MANTIS.

Leisegang MS, Bibli S-I, Günther S, Pflüger-Müller B, Oo JA, Seredinski S, Hu J, Sigala F, Boon RA, Fleming I, Brandes RP. Eur Heart J. 2019;40(30):2523-2533. doi: 10.1093/eurheartj/ehz393.

Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.

Siragusa M, Thöle J, Bibli S-I, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I. EMBO J. 2019;38:e100938. doi: 10.15252/embj.2018100938.

IL27Rα deficiency alters endothelial cell function and subverts tumor angiogenesis in mammary carcinoma.

Fink AF, Ciliberti G, Popp R, Frank A-C, Fleming I, Sekar D, Weigert A, Brüne B. Front. Oncology 2019;9:1022. doi: 10.3389/fonc.2019.01022.

Extracellular RNA released due to shear stress controls natural bypass growth by mediating mechanotransduction.

Lasch M, Kleinert EC, Meister S, Kumaraswami K, Buchheim J-I, Grantzow T, Lautz T, Salpisti S, Fischer S, Troidl K, Fleming I, Randi AM, Sperandio M, Preissner KT, Deindl E. Blood. 2019;134:1469-1479. doi: 10.1182/blood.2019001392.

Regulation of calpain 2 expression by miR-223 and miR-145.

Siuda D, Randriamboavonjy V, Fleming I. BBA Gene Regul Mech. 2019;1862(10):194438. doi: 10.1016/j.bbagrm.2019.194438.

Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation.

Marín-Juez R, Helker CS, El-Sammak H, Kamezaki A, Mullapuli ST, Bibli S-I, Foglia MJ, Fleming I, Poss KD, Stainier DYR. Dev Cell. 2019;51:503-515.e4. doi: 10.1016/j.devcel.2019.10.019.

Soluble epoxide hydrolase promotes astrocyte survival in retinopathy of prematurity.

Hu J, Bibli S-I, Wittig J, Zukunft S, Lin J, Hammes H-P, Popp R, Fleming I. J Clin Invest. 2019;129:5204-5218. doi: 10.1172/JCI123835.

Herzgesundheit: Du bist, was du isst! Über den Einfluss von Diäten, Nahrungsergänzungsmitteln und Probiotika.

Fleming I. von Herzen. 2.2019 ed. 2019. p. 12-5.

SPRED2 deficiency elicits cardiac arrhythmias and premature death via impaired autophagy.

Ullrich M, Assmus B, Augustin AM, Habich H, Abesser M, Martin MJ, Werner F, Erkens R, Arias-Loza AP, Umbenhauer S, Wagner H, Benz PM, Unger A, Linke WA, Frantz S, Baba HA, Kuhn M, Schuh K. J Mol Cell Cardiol. 2019;129:13-26. {Ullrich, 2019 20042 /id}

Tolerizing CTL by sustained hepatic PD-L1 expression provides a new therapy approach in mouse sepsis.

von Knethen A, Schafer A, Kuchler L, Knape T, Christen U, Hintermann E, Fisslthaler B, Schroder K, Brandes RP, Genz B, Abshagen K, Putzer BM, Sha LK, Weigert A, Syed SN, Schulz M, Shah AM, Ernst A, Putyrski M, Finkelmeier F, Pesic M, Greten F, Hogardt M, Kempf VAJ, Gunne S, Parnham MJ, Brune B. Theranostics. 2019;9:2003-2016. {von Knethen, 2019 20041 /id}

*

Indicates that the authors contributed equally; bold names = IVS members

Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by -ketoglutarate and TET-TDG functional reactivation.

Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Künne C, Günther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sueruen D, Schnutgen F, von Melchner H, Di Stilo A, Aragno M, Braspenning M, Van Criekinge W, De Blasio MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. Circ Res. 2018;122:31-46. doi: 10.1161/CIRCRESAHA.117.311300.

The NADPH organizers NoxO1 and p47phox are both mediators of diabetes-induced vascular dysfunction in mice.

Rezende F, Moll F, Walter M, Helfinger V, Hahner F, Janetzko P, Ringel C, Weigert A, Fleming I, Weissmann N, Kuenne C, Looso M, Rieger MA, Nawroth P, Fleming T, Brandes RP, Schröder K. Redox Biol. 2018;15:12-21. doi: 10.1016/j.redox.2017.11.014.

Mitochondrial fragmentation in human macrophages attenuates palmitate-induced inflammatory responses.

Zezina E, Snodgrass RG, Schreiber Y, Zukunft S, Meyer zu Heringdorf D, Geisslinger G, Fleming I, Brüne B, Namgaladze D. Biochem Biophys Acta – Mol Cell Biol Lipids 2018;1863(4):433-46. doi: 10.1016/j.bbalip.2018.01.009.

Phosphorylation of vasodilator-stimulated phosphoprotein contributes to myocardial ischemic preconditioning.

Köhler D, Bibli S-I, Klammer LP, Roth JM, Lehmann R, Fleming I, Granja TF, Straub A, Benz PM,* Rosenberger P.* Basic Res Cardiol 2018;113:11. doi: 10.1007/s00395-018-0667-0.

Role of the angiotensin-converting enzyme in the G-CSF-induced mobilization of progenitor cells.

Kohlstedt K, Trouvain C, Frömel T, Mudersbach T, Henschler R, Fleming I. Basic Res Cardiol. 2018;113:18. doi: 10.1007/s00395-018-0677-y.

VASP regulates leukocyte infiltration, polarization, and vascular repair after ischemia.

Laban H, Weigert A, Zink J, Elgheznawy A, Schürmann C, Günther L, Abdel Malik R, Bothur S, Wingert S, Bremer R, Rieger MA, Brüne B, Brandes RP, Fleming I, Benz PM. J Cell Biol. 2018;217:1503-19. doi: 10.1083/jcb.201702048.

Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naïve mouse embryonic stem cells.

Cencioni C, Spallotta F, Savoia M, Kuenne C, Guenther S, Re A, Wingert S, Rehage M, Sürün D, Siragusa M, Smith J, Schnütgen F, Melchner H, Rieger M, Martelli F, Riccio A, Fleming I, Martelli F, Braun T, Zeiher AM, Farsetti A, Gaetano C. Nat Commun 2018; 9:1281. doi: 10.1038/s41467-018-03668-0.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells.

Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Nat Commun. 2018;9:2292. doi: 10.1038/s41467-018-04602-0.

A selective and sensitive method for quantification of endogenous polysulfide production in biological samples.

Bibli S-I,* Luck B,* Zukunft S, Wittig J, Chen W, Xian M, Papapetropoulos A, Hu J, Fleming I. Redox Biol. 2018;18:295-304. doi: 10.1016/j.redox.2018.07.016.

Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy.

Nicolay JP, Thorn V, Daniel C, Amann K, Siraskar B, Lang F, Hillgruber C, George T, Hoffmann S, Gorzelanny C, Huck V, Mess C, Obser T, Scheppenheim R, Fleming I, Schneider MF, Schneider SW. Sci Rep. 2018;8:10945. doi: 10.1038/s41598-018-28961-2.

Platelet-enriched microRNAs and cardiovascular homeostasis.

Elgheznawy A, Fleming I. Antiox Redox Signal. 2018;29:902-921. doi: 10.1089/ars.2017.7289.

Angiogenesis and vascular stability in eicosanoids and cancer.

Hu J, Frömel T, Fleming I. Cancer Metastasis Rev. 2018;37:425-438. doi: 10.1007/s10555-018-9732-2.

Platelet communication with the vascular wall: role of platelet-derived microparticles and non-coding RNAs.

Randriamboavonjy V, Fleming I. Clin Sci (Lond). 2018;132:1875-1888. doi: 10.1042/CS20180580.

Endothelial AMP-activated kinase α1 phosphorylates eNOS on Thr495 and decreases endothelial NO formation.

Zippel N, Loot AE, Steingl H, Randriamboavonjy V, Fleming I, Fisslthaler B. Int J Mol Sci. 2018;19:E2753. doi: 10.3390/ijms19092753.

aPKC controls endothelial growth by modulating c-Myc via FOXO1 DNA-binding ability.

Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T, Pasha A, Li M, Masuzawa M, Looso M, Steinbacher TuS, Ebnet K, Potente M, Hirose T, Ohno S, Fleming I, Gattenlöher S, Aung PP, Phung T, Yamasaki O, Yanagi T, Umemura H, Nakayama M. Nat Commun. 2018;9:5357 doi: 10.1038/s41467-018-07739-0.

Polarization of human macrophages by interleukin-4 does not require ATP-citrate lyase.

Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B. Front Immunol. 2018;9:2858. doi: 10.3389/fimmu.2018.02858.

Sphingosine kinase 2 modulates retinal neovascularization in the mouse model of oxygen-induced retinopathy.

Eresch J, Stumpf M, Koch A, Vutukuri R, Ferrrirós N, Schreiber Y, Schröder K, Devraj K, Popp R , Hattenbach L-O, Pfeilschifter J, Pfeilschifter W. Invest Opthamol Vis Sci. 2018;59:653-61 {Eresch, 2018 19310 /id}

*Indicates that the authors contributed equally; bold names = IVS members

AMP-activated protein kinase α2 in neutrophils regulates hypoxia-inducible factor-1α and a network of proteins affecting metabolism and vascular repair after ischemia.

Abdel Malik R, Zippel N, Frömel T, Heidler J, Zukunft S, Walzog B, Ansari N, Pampaloni F, Wingert S, Rieger MA, Wittig I, Fisslthaler B, Fleming I. Circ Res. 2017; 120:99-109. doi: 10.1161/CIRCRESAHA.116.309937. (Editorial: Satoh K. AMPKα2 regulates hypoxia-inducible factor-1α stability and neutrophil survival to promote vascular repair after ischemia. Circ Res. 2017;120:8-10)

Cytochrome P450 enzymes but not NADPH oxidases are the source of the NADPH-dependent lucigenin chemiluminescence in membrane assays.

Rezende F, Prior KK, Löwe O, Wittig I, Strecker V, Moll F, Helfinger V, Schnütgen F, Kurrle N, Wempe F, Walter M, Zukunft S, Luck B, Fleming I, Weissmann N, Brandes RP, Schröder K. Free Radic Biol Med. 2017;102:57-66. doi: 10.1016/j.freeradbiomed.2016.11.019.

Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B.

Loroch S, Trabold K, Gambaryan S, Reiß C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walther U, Jurk K. Thromb Haemost. 2017;117:556-569. doi: 10.1160/TH16-07-0515.

Calpain 1 cleaves and inactivates prostacyclin synthase in mesenteric arteries from diabetic mice.

Randriamboavonjy V, Kyselova A, Elgheznawy A, Zukunft S, Wittig I, Fleming I. Basic Res Cardiol. 2017;112:10. doi: 10.1007/s00395-016-0596-8.

Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischemic insult: role of PYK2.

Bibli S-I, Zhou Z, Zukunft S, Fisslthaler B, Andreadou I, Czabo C, Brouckaert P, Fleming I, Papetropoulos A. Cardiovasc Res. 2017;113:926-937. doi: 10.1093/cvr/cvx058.

The role of eNOS on the compensatory regulation of vascular tonus by H2S in mouse carotid arteries.

Ertuna E, Loot AE, Fleming I, Yetik-Anacak G. Nitric Oxide 2017;69:45-50. doi: 10.1016/j.niox.2017.04.007.

S1PR1 on tumor-associated macrophages promotes lymphangiogenesis and metastasis via NLRP3/IL-1β.

Weichand B, Popp R, Dziumbla S, Mora J, Strack E, Elwakeel E, Frank A-C, Scholich K, Pierre S, Syed SN, Olesch C, Ringleb J, Ören B, Döring C, Savi R, Jung M, von Knethen A, Levkau B, Fleming I, Weigert A, Brüne B. J Exp Med. 2017;214(9):2695-2713. doi: 10.1084/jem.20160392.

Effects of soluble CPE on glioma cell migration are associated with mTOR activation and enhanced glucose flux.

Ilina EI, Armento A, Garea L, Penski C, Jennewein L, Harter PN, Zukunft S, Fleming I, Schulte D, Le Guerroue F, Behrends C, Ronellenfitdch MW, Naumann U, Mittelbronn M. Oncotarget. 2017;8(40):67567-67591. doi: 10.18632/oncotarget.18747.

Hydrogen sulfide preserves eNOS function by inhibiting PYK2: implications for cardiomyocyte survival and cardioprotection.

Bibli S-I, Szabo C, Chatzianastasiou A, Luck B, Zukunft S, Fleming I, Papapetropoulos A. Mol Pharmacol. 2017; 92(6):718-730. doi: 10.1124/mol.117.109645.

Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Hu J,* Geyer A,* Dziumbla S, Awwad K, Zeldin DC, Schunck W-H, Popp R, Frömel T, Fleming I. Prostagland Other Lipid Mediat. 2017; 133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002.

Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy.

Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, de Mos J, Awwad K, Frömel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Müller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I. Nature 2017;552:248-52. doi: 10.1038/nature25013. (Editorial: Yanagida & Hla. A dark side to omega-3 fatty acids. Nature News & Views 2017;552)

The endothelial cell.

Fleming I, Meens MJ, Kwak BR. In: Krams R, Bäck M, eds. The ESC Textbook of Vascular Biology. Oxford University Press; 2017. p. 73-90.

Long noncoding RNA MANTIS facilitates endothelial angiogenic function.

Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Günther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Künne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ, Brandes RP. Circulation. 2017;136:65-79

Induction of cardiac dysfunction in developing and adult zebrafish by chronic isoproterenol stimulation.

Kossack M, Hein S, Juergensen L, Siragusa M, Benz A, Katus HA, Most P, Hassel D. J Mol Cell Cardiol. 2017;108:95-105

Insulin keeps PYK-ing on eNOS: enhanced insulin receptor signaling induces endothelial dysfunction.

Siragusa M, Fisslthaler B. Circ Res. 2017;120:748-50. {Siragusa, 2017 18956 /id}

*Indicates that the authors contributed equally; bold names = IVS members

Hypoxia potentiates palmitate-induced pro-inflammatory activation of primary human macrophages.

Snodgrass RG, Boß M, Zezina E, Weigert A, Dehne N, Fleming I, Brüne B, Namgaladze D. J Biol Chem. 2016;291:413-24. doi: 10.1074/jbc.M115.686709.

Pro-inflammatory obesity in aged cannabinoid-2 receptor deficient mice.

Schmitz K, Mangels N, Häussler A, Ferreiros N, Fleming I, Tegeder I. Int J Obesity. 2016;40:366-79. doi: 10.1038/ijo.2015.169.

Unchanged NADPH oxidase activity in Nox1-Nox2-Nox4 triple knockout mice – What do NADPH-stimulated chemiluminescence assays really detect?

Rezende F, Löwe O, Helfinger V, Prior KC, Walter M, Zukunft S, Fleming I, Weissmann N, Shah AM, Brandes RP, Schröder K. Antiox Redox Signal. 2016;24:392-9. doi: 10.1089/ars.2015.6314.

Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury.

Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles-Kursar G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM. Am J Respir Cell Mol Biol. 2016;54:370-83. doi: 10.1165/rcmb.2014-0225OC.

A modified aortic ring assay for the assessment of angiogenic potential in vitro.

Zippel N, Ding Y, Fleming I. Methods Mol Biol. 2016;1430:205-19. doi: 10.1007/978-1-4939-3628-1_14.

Lipocalin-2 from macrophages stimulated by tumor cell-derived sphingosine-1-phosphate promotes lymphangiogenesis and tumor metastasis. 

Jung M, Ören B, Mora J, Mertens C, Dziumbla S, Popp R, Weigert A, Grossmann N, Fleming I, Brüne B. Sci Signal. 2016;9:ra64. doi: 10.1126/scisignal.aaf3241.

Renal cell carcinoma alters endothelial receptor expression responsible for leukocyte adhesion.

Jüngel E, Krüger G, Rutz J, Nelson K, Werner I, Relja B, Seliger B, Fisslthaler B, Fleming I, Tsaur I, Haferkamp A, Blaheta RA. Oncotarget. 2016; 7:20410-24. doi: 10.18632/oncotarget.7804. Correction Published in Oncotarget 2017;:8:1953-1954. doi: 10.18632/oncotarget.14438.

miR-223-IGF-IR signaling in hypoxia- and load-induced right ventricular failure: a novel therapeutic approach.

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Böhm M, Pullamsetti SS, Ghofrani HA, Gödecke A, Jungmann A, Katus HA, Müller OJ, Schermully RT, Fisslthaler B, Seeger W, Fleming I. Cardiovasc Res. 2016; 111:184-93. doi: 10.1093/cvr/cvw065. (Editors choice and Editorial: MicroRNAs and pulmonary hypertension: a tight link. Elia & Condorelli. Cardiovasc Res. 2016;111:163-4)

Angiopoietin-2 mediates thrombin induced monocyte adhesion and endothelial permeability.

Rathnakumar K, Giri H, Satish A, Fisslthaler B, Fleming I, Ram U, Augustin H, Dixit M. J Thromb Haemost. 2016;14:1655-67. doi: 10.1111/jth.13376.

The eNOS signalosome and its link to endothelial dysfuntion.

Siragusa M, Fleming I. Pflügers Arch Eur J Physiol. 2016;468:1125-37. doi: 10.1007/s00424-016-1839-0.

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men.

McManus S, Tejera N, Awwad K, Vauzour D, Rigby N, Fleming I, Cassidy A, Minihane AM. J Lipid Res. 2016;57:1720-7. doi: 10.1194/jlr.M067801. (Accompanying Editorial: EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids. Schunck WH. J Lipid Res. 2016).

β-Catenin is required for endothelial Cyp1b1 regulation influencing metabolic barrier function.

Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K, Corada M, Minardi S, Dejana E, Plate KH, Fleming I, Liebner S. J Neurosci. 2016;36:8921-35. doi: 10.1523/JNEUROSCI.0148-16.2016.

The factor in EDHF: cytochrome P450 derived lipid mediators and vascular signaling.

Fleming I. Vasc Pharmacol. 2016;86:31-40. doi: 10.1016/j.vph.2016.03.001.

The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity.

Mangels N, Awwad K, Wettenmann A, Romagueira Bichara Dos Santos  L, Frömel T, Fleming I. Prostagland Other Lipid Mediat. 2016;125:30-9. doi: 10.1016/j.prostaglandins.2016.05.003.

DDPH, a novel antihypertensive agent, is a potential dual inhibitor of hepatic CYP2D and CYP3A.

Zhu Y, Hu J , He W, Gao X, Ren P, Chen H. Chem Biol Interact. 2016;247:55-63.

Vasodilator-stimulated phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1 in platelets.

Benz P, Laban H, Zink J, Günther L, Walter U, Gambaryan S, Dib K. Cell Commun Sign. 2016 Sep 13;14(1):21

The histone demethylase PHF8 is essential for endothelial cell migration.

Gu L, Hitzel J, Moll F, Kruse C, Abdel Malik R, Preussner J, Looso M, Leisegang MS, Steinhilber D, Brandes RP, Fork C. PLoS ONE. 2016;11:e0146645.

Exposure to carbon ions triggers proinflammatory signals and changes in homeostasis and epidermal tissue organization to a similar extent as photons.

Simoniello P, Wiedemann J, Zink J, Thoennes E, Stange M, Layer PG, Kovacs M, Podda M, Durante M, Fournier C. Frontiers in Oncology. 2016;5:294.

*Indicates that the authors contributed equally; bold names = IVS members

Role of secreted modular calcium binding protein 1 (SMOC1) in transforming growth factor signaling and angiogenesis.

Awwad K, Hu J, Shi L, Mangels N, Abdel Malik R, Zippel N, Fisslthaler B, Eble JA, Pfeilschifter J, Popp R, Fleming I. Cardiovasc Res. 2015;106:284-94. doi: 10.1093/cvr/cvv098.

HIF-2alpha-dependent PAI-1 induction contributes to angiogenesis in hepatocellular carcinoma.

Geis T, Döring C, Popp R, Grossmann N, Fleming I, Hansmann ML, Dehne N, Brüne B. Exp Cell Res. 2015;331:46-57. doi: 10.1016/j.yexcr.2014.11.018.

Whatever happened to the epoxyeicosatrienoic acid-like endothelium-derived hyperpolarizing factor? The identification of novel classes of lipid mediators and their role in vascular homeostasis.

Frömel T, Fleming I. Antioxid Redox Signal. 2015;22:1273-92. doi: 10.1089/ars.2014.6150.

Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer’s disease.

Laske C, Stellos K, Kempter I, Stransky E, Maetzler W, Fleming I, Randriamboavonjy V. Alzheimer’s & Dementia. 2015;11:465-74. doi: 10.1016/j.jalz.2014.06.003.

HIF-2α attenuates lymphangiogenesis by up-regulating IGFBP1 in hepatocellular carcinoma.

Geis T, Popp R, Hu J, Fleming I, Henke N, Dehne N, Brüne B. Biol Cell. 2015;107:175-88. doi: 10.1111/boc.201400079.

Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.

Elgheznawy A, Shi L, Hu J, Wittig I, Laban H, Pircher J, Mann A, Provost P, Randriamboavonjy V, Fleming I. Circ Res. 2015;117:157-65. doi: 10.1161/CIRCRESAHA.117.305784.

Epigenetic regulation of angiogenesis by JARID1B-induced repression of HOXA5.

Fork C, Gu L, Hitzel J, Josipovic I, Hu J, SzeKa Wong M, Ponomareva Y, Albert M, Schmitz SU, Uchida S, Fleming I, Helin K, Steinhilber D, Leisegang MS, Brandes RP. Arterioscler Thromb Vasc Biol. 2015;35:1645-52. doi: 10.1161/ATVBAHA.115.305561.

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction.

Wang SP, Iring A, Strilic B, Juárez JA, Kaur H, Troidl K, Tonack S, Burbiel JC, Müller CE, Fleming I, Lundberg JO, Wettschureck N, Offermanns S. J Clin Invest. 2015;8:3077-3086. doi: 10.1172/JCI81067.

The F-BAR protein NOSTRIN dictates the localization of the muscarinic M3 receptor and regulates cardiovascular function.

Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, Hindemith T, Schermuly RT, Fleming I, Hoffmeister M, Oess S. Circ Res. 2015;117:460-9. doi: 10.1161/CIRCRESAHA.115.306187.

Metformin reduces hyper-reactivity of platelets from patients with polycystic ovary syndrome by improving mitochondrial integrity.

Randriamboavonjy V, Mann AW, Elgheznawy A, Popp R, Rogowski P, Dornauf I, Dröse S, Fleming I. Thromb Haemost. 2015;114:569-78. doi: 10.1160/TH14-09-0797.

MicroRNA-30 mediates anti-inflammatory effects of shear stress and KLF2 via repression of angiopoietin 2.

Demolli S, Doebele C, Doddaballapur A, Lang V, Fisslthaler B, Chavakis E, Vinciguerra M, Sciacca S, Henschler R, Hecker M, Savant S, Augustin HG, Kaluza D, Dimmeler S, Boon RA. J Mol Cell Cardiol. 2015;88:111-9. {Demolli, 2015 18427 /id}

Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase.

Tobias S, Habermeier A, Siuda D, Reifenberg G, Xia N, Closs EI, Förstermann U, Li H. J Geriatr Cardiol. 2015;12:528-39. {Tobias, 2015 18426 /id}

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*Indicates that the authors contributed equally; bold names = IVS members