2024
Health position paper and redox perspectives – Disease burden by transportation noise.
Sørensen M, Pershagen G, Thacher JD, Lanki T, Wicki B, Röösli M, Vienneau D, Cantuaria ML, Schmidt JH, Aasvang GM, Al-Kindi S, Osborne MT, Wenzel P, Sastre J, Fleming I, Schulz R, Hahad O, Kuntic M, Zielonka J, Sies H, Grune T, Frenis K, Münzel T, Daiber A. Redox Biol. 2024;Feb:69:102995. doi: 10.1016/j.redox.2023.102995. Epub 2023 Dec 18.
Role of the soluble epoxide hydrolase in keratinocyte proliferation and sensitivity of skin to inflammatory stimuli.
Naeem Z, Zukunft S, Huard A, Hu J, Hammock BD, Weigert A, Frömel T, Fleming I. Biomed Pharmacother. 2024;171:116127. doi: 10.1016/j.biopha.2024.116127.
Impaired detoxification of trans, 1 trans-2,4-decadienal, an oxidation product from omega-6 fatty acids, alters insulin signaling, gluconeogenesis and promotes microvascular disease.
Qian X, Klatt S, Bennewitz K, Wohlfart DP, Lou B, meng Y, Buettner M, Poschet G, Morgenstern J, Fleming T, Sticht C, Hausser I, Fleming I, Szendroedi J, Nawroth PP, Kroll J. Adv SciAdv Sci. 2024;11::e2302325. doi: 10.1002/advs.202302325.
Endothelial cells drive organ fibrosis in mice by inducing expression of the transcription factor SOX9.
Trogisch FA, Abouissa A, Keles M, Birke A, Fuhrmann M, Dittrich GM, Weinzierl N, Wink E, Cordero J, Elsherbiny A, Martin-Garrido A, Grein S, Hemanna S, Hofmann E, Nicin L, Bibli SI, Airik R, Kispert A, Kist R, Quanchao S, Kürschner SW, Winkler M, Gretz N, Mogler C, Korff T, Koch PS, Dimmeler S, Dobreva G, Heineke J. Sci Transl Med. 2024;16:eabq4581.doi: 10.1126/scitranslmed.abq4581.
Loss of cardiac mitochondrial complex I persulfidation impairs NAD+ homeostasis in aging.
Drekolia MK, Karantanou C, Wittig I, Li Y, Fuhrmann DC, Brüne B, Katsouda A, Hu J, Papapetropoulos A, Bibli SI. Redox Biol. 2024;69:103014.doi: 10.1016/j.redox.2023.103014.
Hemojuvelin mediated hepcidin induction requires both bone morphogenetic protein type I receptors ALK2 and ALK3.
Dogan DY, Urzica EI, Hornung I, Kastl P, Oguama D, Fette FM, Nguyen LH, Rosenbauer F, Zacharowski K, Klingmüller U, Gradhand E, Knethen A von, Popp R, Fleming I, Schrader L, Steinbicker AU. Blood Adv. 2024; doi: 10.1182/bloodadvances.2023012322.
Age-dependent RGS5 loss in Pericytes induces cardiac dysfunction and fibrosis.
Tamiato A, Tombor LS, Fischer A, Muhly-Reinholz M, Vanicek LR, Toğru BN, Neitz J, Glaser SF, Merten M, Rodriguez Morales D, Kwon J, Klatt S, Schumacher B, Günther S, Abplanalp WT, John D, Fleming I, Wettschureck N, Dimmeler S, Luxán G. Circ Res. 2024; In Press. doi: 10.1161/CIRCRESAHA.123.324183.
Erk inhibition as a promising therapeutic strategy for high IL-8-secreting and low SPTAN1-expressing colorectal cancer.
Meier C, La Rocca G, Nawrot V, Fißlthaler B, Overby SJ, Hourfar K, Plotz G, Seidl C, Ziegler P, Wild P, Zeuzem S, Brieger J, Jäger E, Battmann A, Brieger A. Int J Mol Sci. 2024;25:5658. doi: 10.3390/ijms25115658.
*Indicates that the authors contributed equally; bold names = IVS members